Lynch syndrome subtypes and breast cancer

Evidence for breast cancer as an integral part of Lynch syndrome. N Engl J Med. See related research by Lotsari et al. Finally, as 'universal' testing of all colorectal and endometrial cancers for MSI, independent of family history, becomes more standard [ 15 ], a similar approach in breast cancer will be a developing question. Am J Hum Genet.

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Is breast cancer a part of Lynch syndrome?

Hazard ratios were 6. Abstract A long-standing question is whether breast cancer is an integral part of Lynch syndrome, also known as hereditary non-polyposis colorectal cancer. The numbers of participants remain too small to provide a definitive answer, but this retrospective study certainly suggests that, for the breast cancers that show MSI, their DNA repair defects contribute to their progression.

Lynch syndrome subtypes and breast cancer
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Key Points

Several studies have suggested an elevated risk for breast cancer in LS, but the issue remains controversial. Ultimately, to determine whether breast cancer is a component of LS and, more importantly, whether MSI has prognostic or predictive value in breast cancer management, will require larger, population-based prospective studies. By Matthew Stenger Posted: The role of risk-reducing hysterectomy and bilateral salpingo-oophorectomy for PMS2 mutation carriers needs further discussion.

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Lynch syndrome subtypes and breast cancer
Lynch syndrome subtypes and breast cancer
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