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Martone AM, et al. Combined prevalence of frailty and mild cognitive impairment in a population of elderly Japanese people.

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Neurocognitive Endocrine Immune Musculoskeletal Respiratory Cardiovascular Renal Haematological These systems are intricately linked, ie, decline in one area can trigger worsening in another, and the cumulative effect of dysfunction in multiple physiological systems results in frailty. This perpetuates the cycle of physical decline by contributing to low energy and fatigue, reducing exercise capacity and the inherent effects of exercise on muscle building.

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Frailty significantly increases the risk of a number of adverse health outcomes in elderly people, including 3: This is especially true early in the course of frailty, when interventions are more likely to produce improvements in functional abilities.